I only recently started riding with Garmin Vector 3 power meter and the edge 1030, but have been riding since 2011. I’ve logged over 20k miles without the power meter and the platform off center feedback. I’ve adjusted my cleats and seat position, handle bars etc, to what has suited me over the years/miles, and that i find comfortable. I purchased the vector 3 pedals which says my left foot is off center by 11-13 mm on average, and I believe this to be accurate because I can feel the spot on my foot where the pressure is applied and it seems pretty consistent with the feedback, while the right foot does not have the same condition physically and the feedback from the pedals says its nearly perfectly centered. All that said, I don’t think this is a problem necessarily, I tried making adjustments and I certainly could try to adjust my bike to drive the number to zero, I have seen that when standing the number goes to zero/near zero. Adjusting cleat position alone was not enough to correct the number to zero, and additional adjustments may not drive the offset to zero, I suspect it may be my body’s way of adjusting my natural pedal mechanics to provide my left leg (non-dominant) a mechanical advantage by extending the lever arm to even out the torque produced by each leg. If I was experience pain or discomfort I would try to make adjustments, but like some others have stated it may not be desirable to have both feet have zero offset from center. Certainly, zero offset should not take primacy over comfort and fit adjustments that reduce pain. It may be that having significant offset in one or both pedals produces the best case scenario for you. I think this is the case for me, at least on the bike I’m riding for sure. It’s worth noting that I’m toward the top of the size chart on the bike size I’m riding, perhaps if I was in the center of the chart I could make adjustments to have my seated riding positions so that my center of mass is directly above the center of the crank, whereas I’m currently behind the center of the crank in the seated position, since if I was over the center to the crank I’d be too close to the handle bars and would not be uncomfortable. I do think that centering your body with the center fo the crank is key to reducing the platform center offset due to the fact it is reduced to zero on both pedals when I’m standing.