They effectively shift the whole axle to the right (drive side):
With the axle set off-center, it aims to get a more even bracing angle on the spokes, for a stronger and more balanced wheel build.
- Not sure about how moto wheels are set with respect to axle location relative to the bike center?
Regardless, it is unique to Cannondale and requires any “normal” wheel to be re-dished (6mm left) in order to run with this setup. So, despite being “easy”, it is a necessary step and one that many consider to be a hassle (me included).