FWIW I may share some of my journey with retatrutide here. I’ve looked here and in other forums and reddit, and I don’t see a lot of chatter about reta specifically in endurance circles.
For context, I have a decent training history, have done 10+ olympic triathlons and quite a bit of cycling. Was pretty fit in May 2025, then experienced a layoff and had my first baby in July.
Now, with a career change to a much more demanding position and with a 7 month old, I find myself wanting to get back into shape. I’m about 230 lbs, 6 foot even. In a perfect world I’d like to be at 170, but my first step goal is to get back to 200.
At the same time I’m working on implementing cycling again into my routine. With work and the kid, I can no longer work out in the evening. I am not typically a morning person, so this is a big change. I’m starting with 2 30 min rides on Tuesday and thursday before work and an hour session scheduled for saturday.
By the summer, I hope to be a bit lighter and more fit, such that I can take the then 12 month old out in a bike trailer and not be completely dead at pulling 50 plus extra pounds.
I”ve sourced Retatrutide from a vendor that has very high purity ratings from 3rd party testing. I’m going to start slow at .5 mg a week, and slowly titrate up to keep side effects manageable.
The biggest gap in what I’ve read online is endurance training intersecting with the increased heart rate from the added Glucagon agonist. I”m not sure how much my heart rate will be impacted. This will be something I watch closely on my Garmin watch and during workouts.
I’m choosing to augment my weight loss with a GLP1-RA because when I’ve lost weight in the past, it has required a near-neurotic focus all day on food. I simply don’t have that capacity right now. I also realize there is a risk in choosing something not yet FDA approved. I accept that. I am closely following the clinical trials and have noted the cardiac safety signal, hence my focus on it. I chose retatrutide because of its increased effectiveness and improved side effect profile.
I know with weightloss in general and on GLP1-RAs I won’t have the same top end. This seems like an appropriate sacrifice as a high top end won’t matter if I stay this heavy, and I don’t have any races or anything scheduled. Long term, it might be nice to work towards a race or something low-key this fall or next year.
I’ll try to keep this thread updated.
