It’s worth playing around with over the course of a few weeks so that you can get a feel for the different modes. Your personal preferences, how you ride, and the terrain on which you ride will all impact on how each mode works for you.
I tend to have it set on full synchro. For me this works well. Your mileage may vary. Where I live there are lots of very sudden, very steep climbs, so even with the full synchro I am still actively shifting the front chainring more often than relying on the synchro to shift it, but I like the synchro for how it helps me maintain a more even cadence on the longer drags that undulate rather than suddenly pitch up.
One problem I have though is that after I changed my cassette to an 11-32, the app doesn’t allow me to select my exact gearing combination (52/36, 11-32), therefore the synchro shifts no longer match up quite as well as they did previously).
Play around with it and see what you end up liking.