@bbarrera I have a 2020 disc Madone with Pro One 28c on Zipp 303 Firecrest which measure a hair under 32 mm wide. I have at least 5 mm clearance all around the tires and wheels. She rides very smooth as far as the saddle goes but on a road like you pictured or worse the front end does transmit a bit to the hands. This is with carbon bars and stem. Certainly nothing worse than any other bike’s front end I’ve been on (Supersix, gen 1 Domane, Allez, Teammachine) although I haven’t ever ridden something with a front end like a newer Domane.
I’m 150 lbs so I do only run 55/60 psi in the tires. Going to try 50/55 psi for a few rides just to see how it feels.