True, but there is still a notable variation between comparably priced, high end models:
Emonda is still the lightest, Domane is the heaviest and the Madone is in the middle (but closer to the Domane).
All have some aero features, with the Madone predictably taking it the furthest (wheels and frame shaping).
Comfort is king for the Domane (front and rear IsoSpeed), Madone has some (with rear IsoSpeed), and Emonda is last (relies on seat mast design for flex). Domane will rule on max tire size (38mm) with Modone (28mm) and Emonda (28mm).
Much depends on your tolerance for weight, and potential for goals on comfort and/or tire size.
Then geo might play a part as well, since the race bikes are H1.5 fit and the Domane is Endurance fit (H1.5 available in Project One). Can potentially get them all to fit the same, if you aren’t pushing limits on either end. But it may take changes to stem and bars to match your desired fit.