If you’re talking a big ol’ red lump-a-dump on your backside, the chamois is not the issue.
I’ve had a few of those over the decades – nasty buggers that have required antibiotics and sometimes, lancing.
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right saddle. My worst ones came in years when I was “making do” with Flites, and couldn’t find my beloved San Marco Regales.
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right position. too high or too far back can cause pressure and chafing that leads to saddle boils.
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hygiene. I’ve been washing off with Hibiclens before soap and water after each ride, especially indoor ones that turned into sweat fests.
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saddle cream. I dig Chamois Butt’r Euro Style.
I’ve never found one chamois to be better than another – some longer lasting, sure, but they’re all kind of the same once you start pedaling.