What saddle to bar drop are you running and what symptoms you get if it’s too big?
I have Venge 54 with a saddle height of 725mm with 1.5cm spacers and that gives me a 9cm drop.
I can ride in drops for hours but when I climb I have some strange feelings in my hips (while on the hoods).
Before I rode bigger size Tarmac with 6.5cm drop and if I remember the feeling was a bit different (and there is some watts diff also).
But again, that is all maybe in my head or it’s connected with saddle height and not drop.