The easier the indoor ride, the harder it is on your butt. i have a very padded pair of particular bike shorts i use for those rides and keep a neoprene swim cap or hand towel nearby if things get out unbearable. I stupidly decided to ride Stelvio on the trainer one day and this is where i learned desperate times called for desperate measures. The other thing that helps is taking your mind off it, as others suggested, with something to watch or ride a scenic route in Rouvy.
I have this same problem but resist taking a break because I dont want the AI to think Im unable to do the interval. Is this wrong headed?
When you folks mention standing are you standing and pedaling or standing and “coasting?” My Kicker seems to struggle to detect my power once I start pedaling again if I stop for even five seconds. Is this everyones experience or is my Kickr the problem?
I just finished Andrews this afternoon. About a half hour in I decided to stand every 12 minutes for a minute or two and let my cadence drop to 55 or 60. Managed to get through the ride with no issue, thankfully.
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I have a kickr bike and pedaling out of the saddle at low power is really sort of a pain (in the quads!). At any cadence below about 54 the kickr will let go and free spin and I have to spin up again to get back up to erg power. Drives me crazy. It just means I have to spin a little faster while standing than I would want to at low power and it is taxing on my quads to do this just because of the mechanics of keeping a higher cadence at very low power–you kind of have to support your body weight more on your handlebars while you spin your legs–but its worth it for the break by butt gets.
Haven’t found a solution to this. I’ve trying changing the gearing of the kickr as suggested by someone online and that hasn’t helped.
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Stand and pedal… or stand and stretch out. But part of the benefit of indoor training is that you minimize downtime/coasting time, so you’re able to do more work in a shorter period. Coasting defeats the purpose. Keep pressure on the pedals as much as you can, but if you need to stand and stretch out, or (GASP) get off the bike and move around, it’s totally fine.
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I train 100% indoors thru winter and around 16-20 hours weekly. I pedal standing about every 10 mins for 1 min. Or depending on the interval I’ll stand for the first min or last 1-2 minutes. I stand a lot outdoors as well training in the Midwest rolling hills. Not only does it relieve saddle pressure but also feels good to stretch the legs and breaks the monotony. (see cadence line below)
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Just want to reiterate what a few others have said here - the quality, and age, of your bibs makes a big difference. I have 2 old sets of Pearl Izumi bibs, and 2 sets of the same ones, but about 18 months newer. The old ones are fine for 60-90 minute rides but I still notice a HUGE difference between those and the new ones. The new ones are definitely where I turn for longer rides.
I’d suggest keeping a better pair of shorts (if others are older) for your longer and lower intensity rides.
that is an incredibly satisfyingly neat and tidy workout graphic 
well done sir 
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Thank you for all the suggestions. Simply standing up every 10 minutes has already made substantial improvements to my sit bone aches. I plan to add a simple homemade rocker to see if I get additional benefits.