Difference between aero and endurance road bikes

I’ve got a 2015 Domane (gen1) and would love to upgrade to Madone, need to kill this browser tab that has been hanging around for the last week or two:
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List price in US for the two I’d consider - $4700 for the SL6 and $7000 for SLR6. But I’m cheap and will just keep on keeping on the Domane… maybe its time for another lottery ticket?!

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