Yes. I run ‘hybrid’ setups on my road and TT bikes.
Road: 52/34 with 11-28 rear for local riding, and 11-32 for the Alps. Sram Red ETAP.
TT: 53/36 with 11-28 rear. Shimano Ultegra Mechanical.
Both bikes are short cage rear mechs.
All setups work fine, I have also used a 33 front for the Fred Whitton (I was gad of that!) - you have to be very careful not to cross-chain with the 52F/32R combo, and for the best results be ‘mechanically sympathetic’ when shifting (take the load off, don’t do changes whilst standing etc).
I have a chain catcher on the roady, and would be lying if I said that I have never dropped a chain, but it’s so infrequent that I never think about it, and because I am not under load when changing gear, i can often catch it and use the mech to flick the chain back on without stopping.
I wouldn’t hesitate to run this combo, but wouldn’t advise it for a newbie or to someone who is a gear masher and likes full power shifts.
Oh, and you will want the 52/11 in the Alps, in fact any long downhill needs more than a 50/11 IMO.