I use the small chainring and whatever cog at the back to keep a straight chain line.
My “natural” cadence with the big ring was too high (~105… closer to 110 some days) so I changed to the small ring a while ago. My cadence now is closer to 90rpm
Pass the initial ride on sand feel, I now prefer it, as it helps me to have a better power distribution during the stroke as result of the trainer being able to better overpower the flywheel.
It doesn’t mean that it will be the same to everyone though. So do some experimenting.