Training for "BIG" Climbs

I can most definitely ride for more than 3 hours. My longest rides being a bit over 5 hours. I have done GMR twice, both times with a longish approach to the start of the segment. Round trips of about 63 and 66 miles. I have thought about driving to the base of the segment and start there, but that seems like it would not be as challenging as with the long approach.