SRAM Eagle AXS Question

I have a set of Santa Cruz Reserve wheels with a Shimano hub (boost). I am looking to get a new bike with XO1 AXS on it (including a set of wheels with XD driver in the rear). The idea would be to be able to change wheelsets to change from XC to more aggressive tires. I hear AXS works with Shimano cassettes but I wonder how difficult it is to switch the rear tire that has the manufacturer fitted Eagle cassette to the SC Reserve tire with an XT or XTR cassette (12-spd) without having to mess with b screws and adjustment gizmos that apparently are required for smooth shifting with SRAM. I have always had shimano drivertrains which have been quite reliable and did not require messing about. How deep does the rabbit hole go if I try this?