I asked a similar question in the past: 1x curious, let's talk about it (road bikes only)
Since then I ended up buying a the SRAM 48T 1x aero chainring and ran that for a while with my factory 10-33 cassette. It was actually pretty great but I wanted taller gears so I didn’t have to spin as fast at higher speeds. I ended up buying a 52T 1x chainring and ran that for a while, but then I jumped in the deep end and went to the SRAM 56T 1x aero chainring with the new red 10-36 cassette. I live in a mountainous area and I still love it. Every climb is basically a threshold or V02 interval but I’m stronger than ever and descents are very exciting.
If you go to a 50T 1x with 10-52 I’d suggest to try to role-play a bit with your existing setup to see if you’ll be ok with the jumps in the 10-52 cassette. When you’re riding instead of switching 1 gear at a time always switch at least 2 at a time and see if that bothers you. If it seems fine you’ll probably be ok with the 10-52. One thing to also consider – Since you’ll likely need a new rear derailleur anyway you might as well consider the new SRAM XPLR 10-46 cassette & derailleur. The jumps between gears will be a little smaller (at the detriment to a little climbing gear range). This is predicated on the Melee being UDH compatible though.