Yes, but they seem to do one thing at the expense of another. I have zero numbness or pressure when on an ISM saddle, but they just murder my sit bones. All of the pressure is on those bones, and instead of having to take breaks to get bloodflow back into my junk, I have to take breaks because my undercarriage just can’t take any more.
Granted, my seat is several years old, so newer models may have designed this out. If you’re having pressure problems, and want to alleviate them for shorter indoor workouts, I would recommend it; I’m not sure if they’re going to be better, overall, when outside.