Yes. I did this for more than a year on both Shimano DA 9000 & 9100. Works fine. Adjust B limit screw most of the way in keep from cross-chaining. I put a slightly longer chain on and was able to cross chain without permanent equipment damage… just sounded a little bad and was an immediate reminder to get out of that 53-32 gear in the rare case I was accidentally in it.
I don’t know about praxis but with Shimano you can put a 34t chainring with a 53t chainring. Shifting quality is marginally diminished but only so far that it would matter for top level racing. Totally fine for me.
If you can’t make the gearing changes, and happen to have longer cranks lying around, that can help with the feel of it all. Much easier to operate at 50-80rpm at threshold power using 175mm cranks by comparison to 155mm cranks.
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