Saddles are very personal, so be prepared to experiment.
I have an ISM Adamo Prologue on my TT bike but it wouldn’t work for me on my road bike because of the different position.
Do any of the Specialized saddles she’s tried have a cut-out? I have a 155 Oura on my road bike and I went from not being able to ride 20k because of discomfort to basically no saddle issues at all.