I don’t have a problem on my Warbird with GRX Di2.
Are you also shifting to the smaller cogs in the rear and small ring up front? That combo is my preference and gives max movement via chain length.
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Small ring in front, clutch off, and then 3rd biggest gear in the back (Di2 doesn’t allow for higher gear with small ring up front)
So weird, maybe I just need to be OK with deflating the tire if I need to remove the wheel?
I mean, I can get it off, it just requires x100 more push and violence than regular Di2 Ultegra on my Venge…
Running 650b with 47mm Pathfinder Pros.
Feel like the biggest n00b ever now… How to install the Shimano GRX 810 rear derailleur (ONLY) onto the frame. - YouTube
I had the tags on the wrong place for the hanger, too far down. So the two tabs in green has to be BEHIND the hanger tab, not between the two tabs…
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That would do it, by leaving the entire assembly rotated too far forward. Glad you figured it out 
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Thanks for the help as well, got my brain thinking and it makes sense with everything being too far forward
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this ^^^